Opportunity Information: Apply for PAR 16 384
The Chemical Discovery (CHEM) Award (R21/R33) grant opportunity (Funding Opportunity Number PAR-16-384) is a discretionary NIH grant program designed to move new chemistry toward practical tools for substance use disorders (SUDs) research and, ultimately, toward medication-development starting points. The core aim is to support projects that either (1) develop chemical probes that can be used to better understand biological mechanisms relevant to SUDs in basic research settings, or (2) identify and validate new lead chemical scaffolds that are promising enough to justify deeper structure-activity relationship (SAR) work. In plain terms, the program is trying to expand the toolbox of well-characterized molecules that researchers can use to test hypotheses about addiction biology, and at the same time seed early-stage drug discovery by finding fresh chemotypes that could be optimized later.
Mechanistically, the R21/R33 format reflects a phased approach often used when a project has an exploratory component followed by a more advanced development component. The R21 phase typically supports early, high-impact feasibility work (for example, initial discovery, early proof-of-concept, or establishing that a probe or scaffold behaves as intended). If predefined milestones are met, the project can transition into the R33 phase, which supports more substantial development (for example, improving potency or selectivity, expanding profiling, and generating data that makes the molecule broadly useful as a research probe or credible as a lead series). This structure is meant to reduce risk for both investigators and the funder by tying later-stage support to measurable progress.
The opportunity sits in the Education and Health funding activity category and is associated with CFDA number 93.279. The source information lists an award ceiling of $200,000, indicating an upper bound on award size as presented in the summary record. The FOA was created on 2016-08-01, and the original closing date shown is 2019-09-07, which signals that the specific posting referenced is tied to that historical submission window.
Eligibility is broad and intentionally inclusive, spanning many types of organizations that could contribute to chemical probe or early lead discovery. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses. The listing also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and even non-U.S. (foreign) entities. That mix reflects NIH’s interest in drawing from academic, government, nonprofit, and industry capabilities, including medicinal chemistry and chemical biology expertise that may sit outside traditional academic settings.
Overall, the CHEM Award is best understood as targeted early-stage chemical discovery funding focused on SUD biology: create or refine molecules that can illuminate mechanisms in the lab, and identify chemical starting points that could later be optimized into stronger probes or eventual therapeutic candidates.Apply for PAR 16 384
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Chemical Discovery (CHEM) Award (R21/R33)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2016-08-01.
- Applicants must submit their applications by 2019-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 16 384) also looked into and applied for these:
| Funding Opportunity |
|---|
| Oncology Co-Clinical Imaging Research Resources to Encourage Consensus on Quantitative Imaging Methods and Precision Medicine (U24) Apply for PAR 16 385 Funding Number: PAR 16 385 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Surgical Disparities Research (R01) Apply for PAR 16 391 Funding Number: PAR 16 391 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploratory/Developmental Surgical Disparities Research (R21) Apply for PAR 16 392 Funding Number: PAR 16 392 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| NIDA Program Project Grant Applications (P01) Apply for PAR 16 393 Funding Number: PAR 16 393 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Secondary Analyses of Alcohol and Chronic Disease (R03) Apply for PA 16 394 Funding Number: PA 16 394 Agency: National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| Secondary Analyses of Alcohol and Chronic Disease (R01) Apply for PA 16 395 Funding Number: PA 16 395 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Engineering Next-Generation Human Nervous System Microphysiological Systems (R21) Apply for PAR 16 397 Funding Number: PAR 16 397 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| NCI Mentored Clinical Scientist Research Career Development Award to Promote Diversity (K08) Apply for PAR 16 400 Funding Number: PAR 16 400 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Engineering Next-Generation Human Nervous System Microphysiological Systems (R01) Apply for PAR 16 398 Funding Number: PAR 16 398 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Mentored Patient-Oriented Research Career Development Award to Promote Diversity (K23) Apply for PAR 16 399 Funding Number: PAR 16 399 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Mentored Research Scientist Development Award to Promote Diversity (K01) Apply for PAR 16 401 Funding Number: PAR 16 401 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NLM Express Research Grants in Biomedical Informatics (R01) Apply for PAR 16 404 Funding Number: PAR 16 404 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| NCI Outstanding Investigator Award (R35) Apply for PAR 16 411 Funding Number: PAR 16 411 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Core Clinical Centers for the Blood and Marrow Transplant Clinical Trials Network (UG1) Apply for RFA HL 17 018 Funding Number: RFA HL 17 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Limited Competition: Data Coordinating Center for the Blood and Marrow Transplant Clinical Trials Network (U24) Apply for RFA HL 17 019 Funding Number: RFA HL 17 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Small Grants Program for Cancer Research (NCI Omnibus R03) Apply for PAR 16 416 Funding Number: PAR 16 416 Agency: National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| NLM Grants for Scholarly Works in Biomedicine and Health (G13) Apply for PAR 16 417 Funding Number: PAR 16 417 Agency: National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| NLM Information Resource Grants to Reduce Health Disparities (G08) Apply for RFA LM 17 002 Funding Number: RFA LM 17 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| "High" or "Medium" Priority AIDS Research on Non-AIDS-defining or AIDS-defining Cancers (R21) Apply for PA 16 425 Funding Number: PA 16 425 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| "High" or "Medium" Priority AIDS Research on Non-AIDS-defining or AIDS-defining Cancers (R01) Apply for PA 16 426 Funding Number: PA 16 426 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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